中文簡介

藥物代謝與處置將考慮發(fā)表原創(chuàng)性研究結果的原稿，這些原稿對異種生物代謝、轉運和處置方面提供重要和新穎的信息。外源生物一詞包括治療劑和環(huán)境化學品。研究可能涉及使用體內或體外方法，包括培養(yǎng)細胞和異種表達系統。鼓勵編寫描述異種代謝和轉運機制方面的手稿，以及研究影響藥物代謝酶和轉運體表達和調控的機制的手稿，包括遺傳變異的手稿。與影響化學物質生物命運的遺傳、營養(yǎng)或激素因素有關的手稿也很有價值，處理異種生物代謝的毒理后果的手稿也很有價值。我們繼續(xù)歡迎描述代謝物鑒定和/或負責特定代謝途徑的特定酶的鑒定的手稿，只要研究是徹底和嚴格的。現邀請?zhí)峤凰幬飫恿�學/藥效學研究結果的手稿，說明藥物處置和反應機制以及/或明確界定的假設。不鼓勵缺乏機械洞察力的研究或只處理描述性的母體藥物藥代動力學。

　　英文簡介

Drug Metabolism and Disposition will consider for publication manuscripts describing the results of original research that contribute significant and novel information on xenobiotic metabolism, transport, and disposition. The term xenobiotic includes therapeutic agents as well as environmental chemicals. Research may involve the use of in vivo or in vitro approaches, including cultured cells and heterologous expression systems. Manuscripts that describe mechanistic aspects of xenobiotic metabolism and transport as well as those examining mechanisms that affect expression and regulation of drug-metabolizing enzymes and transporters, including genetic variability, are encouraged. Manuscripts concerned with genetic, nutritional, or hormonal factors that influence the biological fate of chemicals are also of interest, as are those that address the toxicologic consequences of xenobiotic metabolism. We continue to welcome manuscripts describing metabolite identification and/or identification of specific enzymes responsible for particular metabolic pathways, provided that the studies are thorough and rigorous. Manuscripts presenting the results of pharmacokinetic/pharmacodynamic studies that address mechanisms underlying drug disposition and response and/or address clearly defined hypotheses are invited. Studies lacking mechanistic insight or dealing only with descriptive parent drug pharmacokinetics are not encouraged.

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